Abstract This study employs machine learning to detect the severity of major depressive disorder (MDD) through binary and multiclass classifications. We compared models that used only biomarkers of oxidative stress with those that incorporate sociodemographic and health-related factors. Data collected from 830 participants. based on the Patient Health Questionnaire (PHQ-9) score. https://parisnaturalfoodes.shop/product-category/neem-oil/